Although a few people are already ranting on about it being “boring”, I’m a fan of Twitter Bootstrap, largely because it accomplishes what a zillion people tried before and failed to achieve: a reusable set of web UI components that have a halfway decent (but, overall, coherent) design and that cover most of the use cases for (in my particular case) back-office tools and simple sites, making it easy for you to do things that look halfway decent with the least possible amount of effort from the get go.
It seems to be spawning a few interesting extras that dovetail nicely into it, which I’ll try to keep track of here:
Of course, the purists among you might prefer something like Zurb Foundation, and that’s okay too. As long as you can choose what is best for you.